Natural and Orthogonal Interaction framework for modeling gene-environment interactions with application to lung cancer

OBJECTIVES: We aimed at extending the natural and orthogonal interaction (NOIA) framework, developed for modeling gene-gene interactions in the analysis of quantitative traits, to allow for reduced genetic models, dichotomous traits, and gene-environment interactions. We evaluate the performance of...

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Main Authors: Ma, Jianzhong, Xiao, Feifei, Xiong, Momiao, Andrew, Angeline S, Brenner, Hermann, Duell, Eric J., Haugen, Aage, Hoggart, Clive, Hung, Rayjean J., Lazarus, Philip, Liu, Changlu, Matsuo, Keitaro, Mayordomo, Jose Ignacio, Schwartz, Ann G., Staratschek-Jox, Andrea, Wichmann, Erich, Yang, Ping, Amos, Christopher I.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534768/
https://ncbi.nlm.nih.gov/pubmed/22889990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000339906
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