Relative Mitochondrial Priming of Malignant Myeloblasts and Normal HSCs Determines Chemotherapeutic Success in AML

Despite decades of successful use of cytotoxic chemotherapy in acute myelogenous leukemia (AML), the biological basis for its differential success among individuals and for the existence of a therapeutic index has remained obscure. Rather than taking a genetic approach favored by many, we took a fun...

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Detalhes bibliográficos
Main Authors: Vo, Thanh-Trang, Ryan, Jeremy, Carrasco, Ruben, Neuberg, Donna, Rossi, Derrick J., Stone, Richard, DeAngelo, Daniel J., Frattini, Mark G., Letai, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534747/
https://ncbi.nlm.nih.gov/pubmed/23063124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.08.038
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