Alaska Native smokers and smokeless tobacco users with slower CYP2A6 activity have lower tobacco consumption, lower tobacco-specific nitrosamine exposure and lower tobacco-specific nitrosamine bioactivation

Nicotine, the psychoactive ingredient in tobacco, is metabolically inactivated by CYP2A6 to cotinine. CYP2A6 also activates procarcinogenic tobacco-specific nitrosamines (TSNA). Genetic variation in CYP2A6 is known to alter smoking quantity and lung cancer risk in heavy smokers. Our objective was to...

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Detalhes bibliográficos
Main Authors: Zhu, Andy Z.X., Binnington, Matthew J., Renner, Caroline C., Lanier, Anne P., Hatsukami, Dorothy K., Stepanov, Irina, Watson, Clifford H., Sosnoff, Connie S., Benowitz, Neal L., Tyndale, Rachel F.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
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Original Manuscript
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534190/
https://ncbi.nlm.nih.gov/pubmed/23027621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs306
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