Establishment, Characterization and Chemosensitivity of Three Mismatch Repair Deficient Cell Lines from Sporadic and Inherited Colorectal Carcinomas

BACKGROUND: Colorectal cancer (CRC) represents a morphologic and molecular heterogenic disease. This heterogeneity substantially impairs drug effectiveness and prognosis. The subtype of mismatch repair deficient (MMR-D) CRCs, accounting for about 15% of all cases, shows particular differential respo...

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Main Authors: Maletzki, Claudia, Stier, Saskia, Gruenert, Ulrike, Gock, Michael, Ostwald, Christiane, Prall, Friedrich, Linnebacher, Michael
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534085/
https://ncbi.nlm.nih.gov/pubmed/23300683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052485
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