Dendritic cell CNS recruitment correlates with disease severity in EAE via CCL2 chemotaxis at the blood–brain barrier through paracellular transmigration and ERK activation

BACKGROUND: Transmigration of circulating dendritic cells (DCs) into the central nervous system (CNS) across the blood–brain barrier (BBB) has not thus far been investigated. An increase in immune cell infiltration across the BBB, uncontrolled activation and antigen presentation are influenced by ch...

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Autors principals: Sagar, Divya, Lamontagne, Anne, Foss, Catherine A, Khan, Zafar K, Pomper, Martin G, Jain, Pooja
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533869/
https://ncbi.nlm.nih.gov/pubmed/23102113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-245
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