Inverting the Regioselectivity of the Berberine Bridge Enzyme by Employing Customized Fluorine-Containing Substrates

Fluorine is commonly applied in pharmaceuticals to block the degradation of bioactive compounds at a specific site of the molecule. Blocking of the reaction center of the enzyme-catalyzed ring closure of 1,2,3,4-tetrahydrobenzylisoquinolines by a fluoro moiety allowed redirecting the berberine bridg...

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Detalhes bibliográficos
Main Authors: Resch, Verena, Lechner, Horst, Schrittwieser, Joerg H, Wallner, Silvia, Gruber, Karl, Macheroux, Peter, Kroutil, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533790/
https://ncbi.nlm.nih.gov/pubmed/22962029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201201895
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