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Catalytic and Structural Role of a Conserved Active Site Histidine in Berberine Bridge Enzyme

[Image: see text] Berberine bridge enzyme (BBE) is a paradigm for the class of bicovalently flavinylated oxidases, which catalyzes the oxidative cyclization of (S)-reticuline to (S)-scoulerine. His174 was identified as an important active site residue because of its role in the stabilization of the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wallner, Silvia, Winkler, Andreas, Riedl, Sabrina, Dully, Corinna, Horvath, Stefanie, Gruber, Karl, Macheroux, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2012
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413249/
https://ncbi.nlm.nih.gov/pubmed/22757961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300411n
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