Disassociation of insulin action and Akt/FOXO signaling in skeletal muscle of older Akt-deficient mice

The purpose of the present study was to determine the effect of Akt gene ablation on Akt/Forkhead Box O (FOXO) signaling and atrogene expression. This was accomplished by studying wild-type (WT) and isoform-specific Akt knockout (Akt1(−/−) and Akt2(−/−)) mice. The ability of insulin to promote Akt p...

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Bibliografiset tiedot
Päätekijät: Reynolds, Thomas H., Merrell, Erin, Cinquino, Nicholas, Gaugler, Megan, Ng, Lily
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Physiological Society 2012
Aiheet:
Obesity, Diabetes and Energy Homeostasis
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533617/
https://ncbi.nlm.nih.gov/pubmed/23100026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00358.2012
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