Gain of glycosylation in integrin α3 causes lung disease and nephrotic syndrome

Integrins are transmembrane αβ glycoproteins that connect the extracellular matrix to the cytoskeleton. The laminin-binding integrin α3β1 is expressed at high levels in lung epithelium and in kidney podocytes. In podocytes, α3β1 associates with the tetraspanin CD151 to maintain a functional filtrati...

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Detalhes bibliográficos
Main Authors: Nicolaou, Nayia, Margadant, Coert, Kevelam, Sietske H., Lilien, Marc R., Oosterveld, Michiel J.S., Kreft, Maaike, van Eerde, Albertien M., Pfundt, Rolph, Terhal, Paulien A., van der Zwaag, Bert, Nikkels, Peter G.J., Sachs, Norman, Goldschmeding, Roel, Knoers, Nine V.A.M., Renkema, Kirsten Y., Sonnenberg, Arnoud
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533548/
https://ncbi.nlm.nih.gov/pubmed/23114595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64100
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