Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung

Mucinous adenocarcinoma of the lung is a subtype of highly invasive pulmonary tumors and is associated with decreased or absent expression of the transcription factor NK2 homeobox 1 (NKX2-1; also known as TTF-1). Here, we show that haploinsufficiency of Nkx2-1 in combination with oncogenic Kras(G12D...

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Autors principals: Maeda, Yutaka, Tsuchiya, Tomoshi, Hao, Haiping, Tompkins, David H., Xu, Yan, Mucenski, Michael L., Du, Lingling, Keiser, Angela R., Fukazawa, Takuya, Naomoto, Yoshio, Nagayasu, Takeshi, Whitsett, Jeffrey A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533546/
https://ncbi.nlm.nih.gov/pubmed/23143308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64048
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