Hydrophobic Amino Acids in the Hinge Region of the 5A Apolipoprotein Mimetic Peptide are Essential for Promoting Cholesterol Efflux by the ABCA1 Transporter

The bihelical apolipoprotein mimetic peptide 5A effluxes cholesterol from cells and reduces inflammation and atherosclerosis in animal models. We investigated how hydrophobic residues in the hinge region between the two helices are important in the structure and function of this peptide. By simulate...

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Bibliographic Details
Main Authors: Sviridov, Denis O., Andrianov, Alexander M., Anishchenko, Ivan V., Stonik, John A., Amar, Marcelo J. A., Turner, Scott, Remaley, Alan T.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2013
Subjects:
Cardiovascular
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533411/
https://ncbi.nlm.nih.gov/pubmed/23042953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.198143
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