Novel Screening Assay for the Selective Detection of G-Protein-Coupled Receptor Heteromer Signaling

Drugs targeting G-protein-coupled receptors (GPCRs) make up more than 25% of all prescribed medicines. The ability of GPCRs to form heteromers with unique signaling properties suggests an entirely new and unexplored pool of drug targets. However, current in vitro assays are ill equipped to detect he...

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Bibliografiske detaljer
Main Authors: van Rijn, Richard M., Harvey, Jessica H., Brissett, Daniela I., DeFriel, Julia N., Whistler, Jennifer L.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2013
Fag:
Drug Discovery and Translational Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533407/
https://ncbi.nlm.nih.gov/pubmed/23097213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.198655
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