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Novel Screening Assay for the Selective Detection of G-Protein-Coupled Receptor Heteromer Signaling
Drugs targeting G-protein-coupled receptors (GPCRs) make up more than 25% of all prescribed medicines. The ability of GPCRs to form heteromers with unique signaling properties suggests an entirely new and unexplored pool of drug targets. However, current in vitro assays are ill equipped to detect he...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3533407/ https://ncbi.nlm.nih.gov/pubmed/23097213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.198655 |
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