Phosphoinositide-Dependent Kinase-1 and Protein Kinase Cδ Contribute to Endothelin-1 Constriction and Elevated Blood Pressure in Intermittent Hypoxia

Obstructive sleep apnea (OSA) is associated with cardiovascular complications including hypertension. Previous findings from our laboratory indicate that exposure to intermittent hypoxia (IH), to mimic sleep apnea, increases blood pressure in rats. IH also increases endothelin-1 (ET-1) constrictor s...

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Autori principali: Webster, Bradley R., Osmond, Jessica M., Paredes, Daniel A., DeLeon, Xavier A., Jackson-Weaver, Olan, Walker, Benjimen R., Kanagy, Nancy L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2013
Soggetti:
Cardiovascular
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533405/
https://ncbi.nlm.nih.gov/pubmed/23093023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.195412
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