Phosphoinositide-Dependent Kinase-1 and Protein Kinase Cδ Contribute to Endothelin-1 Constriction and Elevated Blood Pressure in Intermittent Hypoxia

Obstructive sleep apnea (OSA) is associated with cardiovascular complications including hypertension. Previous findings from our laboratory indicate that exposure to intermittent hypoxia (IH), to mimic sleep apnea, increases blood pressure in rats. IH also increases endothelin-1 (ET-1) constrictor s...

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Autores principales: Webster, Bradley R., Osmond, Jessica M., Paredes, Daniel A., DeLeon, Xavier A., Jackson-Weaver, Olan, Walker, Benjimen R., Kanagy, Nancy L.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2013
Materias:
Cardiovascular
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533405/
https://ncbi.nlm.nih.gov/pubmed/23093023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.195412
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