Detection of Tumor PIK3CA Status in Metastatic Breast Cancer Using Peripheral Blood

PURPOSE: We sought to evaluate the feasibility of detecting PIK3CA mutations in circulating tumor DNA (ctDNA) from plasma of patients with metastatic breast cancer using a novel technique called BEAMing. EXPERIMENTAL DESIGN: In a retrospective analysis, 49 tumor and temporally matched plasma samples...

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Detalhes bibliográficos
Main Authors: Higgins, Michaela J., Jelovac, Danijela, Barnathan, Evan, Blair, Brian, Slater, Shannon, Powers, Penny, Zorzi, Jane, Jeter, Stacie C., Oliver, George R., Fetting, John, Emens, Leisha, Riley, Carol, Stearns, Vered, Diehl, Frank, Angenendt, Philipp, Huang, Peng, Cope, Leslie, Argani, Pedram, Murphy, Kathleen M., Bachman, Kurtis E., Greshock, Joel, Wolff, Antonio C., Park, Ben H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533370/
https://ncbi.nlm.nih.gov/pubmed/22421194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2696
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