Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis

Bacterial LPS (endotoxin) has been implicated in the pathogenesis of acute liver disease through its induction of the proinflammatory cytokine TNF-α. TNF-α is a key determinant of the outcome in a well-established mouse model of acute liver failure during septic shock. One possible mechanism for reg...

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Main Authors: González-Terán, Bárbara, Cortés, José R., Manieri, Elisa, Matesanz, Nuria, Verdugo, ρngeles, Rodríguez, María E., González-Rodríguez, ρgueda, Valverde, ρngela, Martín, Pilar, Davis, Roger J., Sabio, Guadalupe
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533299/
https://ncbi.nlm.nih.gov/pubmed/23202732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65124
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