Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

Deposition of amyloid β protein (Aβ) to form neuritic plaques in the brain is the pathological hallmark of Alzheimer’s disease (AD). Aβ is generated from sequential cleavages of the β-amyloid precursor protein (APP) by the β- and γ-secretases, and β-site APP-cleaving enzyme 1 (BACE1) is the β-secret...

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Detalhes bibliográficos
Main Authors: Ly, Philip T.T., Wu, Yili, Zou, Haiyan, Wang, Ruitao, Zhou, Weihui, Kinoshita, Ayae, Zhang, Mingming, Yang, Yi, Cai, Fang, Woodgett, James, Song, Weihong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533290/
https://ncbi.nlm.nih.gov/pubmed/23202730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64516
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