FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2

Mutations in the RNA-binding protein FUS (fused in sarcoma)/TLS have been shown to cause the neurodegenerative disease amyotrophic lateral sclerosis (ALS), but the normal role of FUS is incompletely understood. We found that FUS binds the C-terminal domain (CTD) of RNA polymerase II (RNAP2) and prev...

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Bibliografiske detaljer
Main Authors: Schwartz, Jacob C., Ebmeier, Christopher C., Podell, Elaine R., Heimiller, Joseph, Taatjes, Dylan J., Cech, Thomas R.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2012
Fag:
Research Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533074/
https://ncbi.nlm.nih.gov/pubmed/23249733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.204602.112
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