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TARDBP mutation analysis in TDP-43 proteinopathies and deciphering the toxicity of mutant TDP-43

The identification of TAR DNA-binding protein 43 (TDP-43) as the major disease protein in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin inclusions (FTLD-U) has defined a new class of neurodegenerative conditions: the TDP-43 proteinopathies. This breakthroug...

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Sonraí Bibleagrafaíochta
Main Authors: Gendron, Tania F., Rademakers, Rosa, Petrucelli, Leonard
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532959/
https://ncbi.nlm.nih.gov/pubmed/22751173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2012-129036
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