Human Sarcomas Are Mosaic for Telomerase-Dependent and Telomerase-Independent Telomere Maintenance Mechanisms: Implications for Telomere-Based Therapies

Telomere shortening necessitates that tumor cells activate a telomere maintenance mechanism (TMM) to support immortalization. Although most tumor cells activate expression of the enzyme telomerase, some cells elongate telomeres in a telomerase-independent manner, termed alternative lengthening of te...

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Bibliographic Details
Main Authors: Gocha, April R.S., Nuovo, Gerard, Iwenofu, Obiajulu H., Groden, Joanna
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2013
Subjects:
Short Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532709/
https://ncbi.nlm.nih.gov/pubmed/23260199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.10.001
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