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Enhanced Sensitivity to IL-2 Signaling Regulates the Clinical Responsiveness of IL-12–Primed CD8(+) T Cells in a Melanoma Model

The optimal expansion, trafficking, and function of adoptively transferred CD8(+) T cells are parameters that currently limit the effectiveness of antitumor immunity to established tumors. In this study, we addressed the mechanisms by which priming of self tumor-associated Ag-specific CD8(+) T cells...

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Main Authors: Lisiero, Dominique N., Soto, Horacio, Liau, Linda M., Prins, Robert M.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532507/
https://ncbi.nlm.nih.gov/pubmed/21430221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003317
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