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GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling

Increased gpdh-1 transcription is required for accumulation of the organic osmolyte glycerol and survival of Caenorhabditis elegans during hypertonic stress. Our previous work has shown that regulators of gpdh-1 (rgpd) gene knockdown constitutively activates gpdh-1 expression. Fifty-five rgpd genes...

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Bibliografske podrobnosti
Main Authors: Lee, Elaine Choung-Hee, Strange, Kevin
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532491/
https://ncbi.nlm.nih.gov/pubmed/23076791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00294.2012
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