Smad inhibition by the Ste20 kinase Misshapen

The level of TGF-β/bone morphogenetic protein (BMP) signaling through Smad is tightly regulated to ensure proper embryonic patterning and homeostasis. Here we show that Smad activation by TGF-β/BMP is blocked by a highly conserved phosphorylation event in the α-helix 1 region of Smad [T312 in Drosop...

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Detalhes bibliográficos
Main Authors: Kaneko, Satoshi, Chen, Xiaochu, Lu, Peiyuan, Yao, Xiaohao, Wright, Theodore G., Rajurkar, Mihir, Kariya, Ken-ichi, Mao, Junhao, Ip, Y. Tony, Xu, Lan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131379/
https://ncbi.nlm.nih.gov/pubmed/21690388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104128108
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