Targeted blockade in lethal West Nile virus encephalitis indicates a crucial role for very late antigen (VLA)-4-dependent recruitment of nitric oxide-producing macrophages

Infiltration of Ly6C(hi) monocytes from the blood is a hallmark of viral encephalitis. In mice with lethal encephalitis caused by West Nile virus (WNV), an emerging neurotropic flavivirus, inhibition of Ly6C(hi) monocyte trafficking into the brain by anti-very late antigen (VLA)-4 integrin antibody...

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Detalhes bibliográficos
Main Authors: Getts, Daniel R, Terry, Rachael L, Getts, Meghann Teague, Müller, Marcus, Rana, Sabita, Deffrasnes, Celine, Ashhurst, Thomas Myles, Radford, Jane, Hofer, Markus, Thomas, Shane, Campbell, Iain L, King, Nicholas JC
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532418/
https://ncbi.nlm.nih.gov/pubmed/23111065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-246
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