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MCALIGN: Stochastic Alignment of Noncoding DNA Sequences Based on an Evolutionary Model of Sequence Evolution

A method is described for performing global alignment of noncoding DNA sequences based on an evolutionary model parameterized by the frequency distribution of lengths of insertion/deletion events (indels) and their rate relative to nucleotide substitutions. A stochastic hill-climbing algorithm is us...

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Autors principals: Keightley, Peter D., Johnson, Toby
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2004
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC353231/
https://ncbi.nlm.nih.gov/pubmed/14993209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.1571904
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