Liver-Specific PGC-1beta Deficiency Leads to Impaired Mitochondrial Function and Lipogenic Response to Fasting-Refeeding

PGC-1β plays pleiotropic roles in regulating intermediary metabolism and has been shown to regulate both catabolic and anabolic processes in liver. We sought to evaluate the effects of PGC-1β on liver energy metabolism by generating mice with postnatal, liver-specific deletion of PGC-1β (LS-PGC-1β(−...

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Detalhes bibliográficos
Main Authors: Chambers, Kari T., Chen, Zhouji, Crawford, Peter A., Fu, Xiaorong, Burgess, Shawn C., Lai, Ling, Leone, Teresa C., Kelly, Daniel P., Finck, Brian N.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532159/
https://ncbi.nlm.nih.gov/pubmed/23285128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052645
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