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Identification of a Tetrahydroquinoline Analog as a Pharmacological Inhibitor of the cAMP-binding Protein Epac

The cAMP-binding protein Epac is a therapeutic target for the treatment of various diseases such as cardiac hypertrophy and tumor invasion. This points out the importance to develop Epac inhibitors to better understand the involvement of these cAMP sensors in physiology and pathophysiology. Here, we...

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Detalhes bibliográficos
Main Authors: Courilleau, Delphine, Bisserier, Malik, Jullian, Jean-Christophe, Lucas, Alexandre, Bouyssou, Pascal, Fischmeister, Rodolphe, Blondeau, Jean-Paul, Lezoualc'h, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531735/
https://ncbi.nlm.nih.gov/pubmed/23139415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.422956
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