Defining critical roles for NF-κB p65 and type I interferon in innate immunity to rhinovirus

The importance of NF-κB activation and deficient anti-viral interferon induction in the pathogenesis of rhinovirus-induced asthma exacerbations is poorly understood. We provide the first in vivo evidence in man and mouse that rhinovirus infection enhanced bronchial epithelial cell NF-κB p65 nuclear...

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Hlavní autoři: Bartlett, Nathan W, Slater, Louise, Glanville, Nicholas, Haas, Jennifer J, Caramori, Gaetano, Casolari, Paolo, Clarke, Deborah L, Message, Simon D, Aniscenko, Julia, Kebadze, Tatiana, Zhu, Jie, Mallia, Patrick, Mizgerd, Joseph P, Belvisi, Maria, Papi, Alberto, Kotenko, Sergei V, Johnston, Sebastian L, Edwards, Michael R
Médium: Artigo
Jazyk:Inglês
Vydáno: WILEY-VCH Verlag 2012
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531601/
https://ncbi.nlm.nih.gov/pubmed/23165884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201201650
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