Defining critical roles for NF-κB p65 and type I interferon in innate immunity to rhinovirus

The importance of NF-κB activation and deficient anti-viral interferon induction in the pathogenesis of rhinovirus-induced asthma exacerbations is poorly understood. We provide the first in vivo evidence in man and mouse that rhinovirus infection enhanced bronchial epithelial cell NF-κB p65 nuclear...

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Detalhes bibliográficos
Main Authors: Bartlett, Nathan W, Slater, Louise, Glanville, Nicholas, Haas, Jennifer J, Caramori, Gaetano, Casolari, Paolo, Clarke, Deborah L, Message, Simon D, Aniscenko, Julia, Kebadze, Tatiana, Zhu, Jie, Mallia, Patrick, Mizgerd, Joseph P, Belvisi, Maria, Papi, Alberto, Kotenko, Sergei V, Johnston, Sebastian L, Edwards, Michael R
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531601/
https://ncbi.nlm.nih.gov/pubmed/23165884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201201650
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