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IFNα and LPS up-regulate APOBEC3 (A3) mRNA through different signaling pathways

APOBEC3 (A3) proteins are virus restriction factors that provide intrinsic immunity against infections by viruses like HIV-1 and MMTV. A3 proteins are inducible by inflammatory stimuli such as LPS and IFNα via mechanisms that are not yet fully defined. Using genetic and pharmacological studies on C5...

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Bibliografische gegevens
Hoofdauteurs: Mehta, Harshini V., Jones, Philip H., Weiss, Jerrold P., Okeoma, Chioma M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531240/
https://ncbi.nlm.nih.gov/pubmed/22972924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200777
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