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Srv2/cyclase-associated protein forms hexameric shurikens that directly catalyze actin filament severing by cofilin

Actin filament severing is critical for the dynamic turnover of cellular actin networks. Cofilin severs filaments, but additional factors may be required to increase severing efficiency in vivo. Srv2/cyclase-associated protein (CAP) is a widely expressed protein with a role in binding and recycling...

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Autors principals: Chaudhry, Faisal, Breitsprecher, Dennis, Little, Kristin, Sharov, Grigory, Sokolova, Olga, Goode, Bruce L.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530777/
https://ncbi.nlm.nih.gov/pubmed/23135996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-08-0589
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