P-value-based regulatory motif discovery using positional weight matrices

To analyze gene regulatory networks, the sequence-dependent DNA/RNA binding affinities of proteins and noncoding RNAs are crucial. Often, these are deduced from sets of sequences enriched in factor binding sites. Two classes of computational approaches exist. The first describe binding motifs by seq...

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Bibliographic Details
Main Authors: Hartmann, Holger, Guthöhrlein, Eckhart W., Siebert, Matthias, Luehr, Sebastian, Söding, Johannes
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2013
Subjects:
Method
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530678/
https://ncbi.nlm.nih.gov/pubmed/22990209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.139881.112
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