Genome-wide mapping of human DNA-replication origins: Levels of transcription at ORC1 sites regulate origin selection and replication timing

We report the genome-wide mapping of ORC1 binding sites in mammals, by chromatin immunoprecipitation and parallel sequencing (ChIP-seq). ORC1 binding sites in HeLa cells were validated as active DNA replication origins (ORIs) using Repli-seq, a method that allows identification of ORI-containing reg...

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Hauptverfasser: Dellino, Gaetano Ivan, Cittaro, Davide, Piccioni, Rossana, Luzi, Lucilla, Banfi, Stefania, Segalla, Simona, Cesaroni, Matteo, Mendoza-Maldonado, Ramiro, Giacca, Mauro, Pelicci, Pier Giuseppe
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2013
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530669/
https://ncbi.nlm.nih.gov/pubmed/23187890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.142331.112
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