AL Amyloid Imaging and Therapy with a Monoclonal Antibody to a Cryptic Epitope on Amyloid Fibrils

The monoclonal antibody 2A4 binds an epitope derived from a cleavage site of serum amyloid protein A (sAA) containing a -Glu-Asp- amino acid pairing. In addition to its reactivity with sAA amyloid deposits, the antibody was also found to bind amyloid fibrils composed of immunoglobulin light chains....

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Main Authors: Wall, Jonathan S., Kennel, Stephen J., Williams, Angela, Richey, Tina, Stuckey, Alan, Huang, Ying, Macy, Sallie, Donnell, Robert, Barbour, Robin, Seubert, Peter, Schenk, Dale
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530443/
https://ncbi.nlm.nih.gov/pubmed/23300743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052686
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