Efficacy and immunomodulatory actions of ONO-4641, a novel selective agonist for sphingosine 1-phosphate receptors 1 and 5, in preclinical models of multiple sclerosis

ONO-4641 is a next-generation sphingosine 1-phosphate (S1P) receptor agonist selective for S1P receptors 1 and 5. The objective of the study was to characterize the immunomodulatory effects of ONO-4641 using preclinical data. ONO-4641 was tested in both in-vitro pharmacological studies as well as in...

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Bibliographische Detailangaben
Hauptverfasser: Komiya, T, Sato, K, Shioya, H, Inagaki, Y, Hagiya, H, Kozaki, R, Imai, M, Takada, Y, Maeda, T, Kurata, H, Kurono, M, Suzuki, R, Otsuki, K, Habashita, H, Nakade, S
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2013
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530095/
https://ncbi.nlm.nih.gov/pubmed/23199323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2012.04669.x
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