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Juxtamembrane tryptophans of synaptobrevin 2 control the process of membrane fusion

Synaptobrevin 2 (Syb2), Syntaxin (Sx1A), and SNAP-25, generate a force to induce fusion pore formation. The v-SNARE, Syb2, is anchored to the vesicle membrane by a single transmembrane domain. Here we show that 2 tryptophans (W89/W90) located in the juxtamembrane domain of Syb2, which stabilize the...

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Bibliografske podrobnosti
Main Authors: Fang, Qinghua, Zhao, Ying, Lindau, Manfred
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529983/
https://ncbi.nlm.nih.gov/pubmed/23178715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2012.11.002
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