CYP2C9 Variants Increase Risk of Colorectal Adenoma Recurrence and Modify Associations with Smoking but Not Aspirin Treatment

PURPOSE: The cytochrome P450 2C9 enzyme (CYP2C9) is involved in metabolism of endogenous compounds, drugs and procarcinogens. Two common nonsynonymous polymorphisms in CYP2C9 are associated with reduced enzyme activity: CYP2C9*2 (rs1799853, R144C) and CYP2C9*3 (rs1057910, I359L). METHODS: We investi...

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Главные авторы: Barry, Elizabeth L., Poole, Elizabeth M., Baron, John A., Makar, Karen W., Mott, Leila A., Sandler, Robert S., Ahnen, Dennis J., Bresalier, Robert S., McKeown-Eyssen, Gail E., Ulrich, Cornelia M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529799/
https://ncbi.nlm.nih.gov/pubmed/23081681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10552-012-0088-6
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