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Reactivation of the Silenced Thyroid Hormone Receptor β Gene Expression Delays Thyroid Tumor Progression

That a knock-in mouse harboring a dominant-negative thyroid hormone receptor (TR)-β (Thrb) mutation develops metastatic thyroid cancer strongly suggests the involvement of TRβ in carcinogenesis. Epigenetic silencing of the THRB gene is common in human cancers. The aim of the present study was to det...

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Bibliografiska uppgifter
Huvudupphovsmän: Kim, Won Gu, Zhu, Xuguang, Kim, Dong Wook, Zhang, Lisa, Kebebew, Electron, Cheng, Sheue-yann
Materialtyp: Artigo
Språk:Inglês
Publicerad: Endocrine Society 2013
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529371/
https://ncbi.nlm.nih.gov/pubmed/23183175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1728
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