Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice

Mutations in SPG4, encoding the microtubule-severing protein spastin, are responsible for the most frequent form of hereditary spastic paraplegia (HSP), a heterogeneous group of genetic diseases characterized by degeneration of the corticospinal tracts. We previously reported that mice harboring a d...

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Main Authors: Fassier, Coralie, Tarrade, Anne, Peris, Leticia, Courageot, Sabrina, Mailly, Philippe, Dalard, Cécile, Delga, Stéphanie, Roblot, Natacha, Lefèvre, Julien, Job, Didier, Hazan, Jamilé, Curmi, Patrick A., Melki, Judith
格式: Artigo
語言:Inglês
出版: The Company of Biologists Limited 2013
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529340/
https://ncbi.nlm.nih.gov/pubmed/22773755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.008946
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