Anti-inflammatory lipoxin A(4) is an endogenous allosteric enhancer of CB(1) cannabinoid receptor

Allosteric modulation of G-protein–coupled receptors represents a key goal of current pharmacology. In particular, endogenous allosteric modulators might represent important targets of interventions aimed at maximizing therapeutic efficacy and reducing side effects of drugs. Here we show that the an...

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Main Authors: Pamplona, Fabricio A., Ferreira, Juliano, Menezes de Lima, Octávio, Duarte, Filipe Silveira, Bento, Allisson Freire, Forner, Stefânia, Villarinho, Jardel G., Bellocchio, Luigi, Wotjak, Carsten T., Lerner, Raissa, Monory, Krisztina, Lutz, Beat, Canetti, Claudio, Matias, Isabelle, Calixto, João Batista, Marsicano, Giovanni, Guimarães, Marilia Z. P., Takahashi, Reinaldo N.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529012/
https://ncbi.nlm.nih.gov/pubmed/23150578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202906109
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