Anti-inflammatory lipoxin A(4) is an endogenous allosteric enhancer of CB(1) cannabinoid receptor

Allosteric modulation of G-protein–coupled receptors represents a key goal of current pharmacology. In particular, endogenous allosteric modulators might represent important targets of interventions aimed at maximizing therapeutic efficacy and reducing side effects of drugs. Here we show that the an...

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Autors principals: Pamplona, Fabricio A., Ferreira, Juliano, Menezes de Lima, Octávio, Duarte, Filipe Silveira, Bento, Allisson Freire, Forner, Stefânia, Villarinho, Jardel G., Bellocchio, Luigi, Wotjak, Carsten T., Lerner, Raissa, Monory, Krisztina, Lutz, Beat, Canetti, Claudio, Matias, Isabelle, Calixto, João Batista, Marsicano, Giovanni, Guimarães, Marilia Z. P., Takahashi, Reinaldo N.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529012/
https://ncbi.nlm.nih.gov/pubmed/23150578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202906109
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