A Droplet Microfluidics Platform for Highly Sensitive and Quantitative Detection of Malaria Causing Plasmodium Parasites Based on Enzyme Activity Measurement

We present an attractive new system for the specific and sensitive detection of the malaria causing Plasmodium parasites. The system relies on isothermal conversion of single DNA cleavage-ligation events catalyzed specifically by the Plasmodium enzyme topoisomerase I to micrometer sized products det...

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Detalhes bibliográficos
Main Authors: Juul, Sissel, Nielsen, Christine J. F., Labouriau, Rodrigo, Roy, Amit, Tesauro, Cinzia, Jensen, Pia W., Harmsen, Charlotte, Kristoffersen, Emil L., Chiu, Ya-Ling, Frøhlich, Rikke, Fiorani, Paola, Cox-Singh, Janet, Tordrup, David, Koch, Jørn, Bienvenu, Anne-Lise, Desideri, Alessandro, Picot, Stephane, Petersen, Eskild, Leong, Kam W., Ho, Yi-Ping, Stougaard, Magnus, Knudsen, Birgitta R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528816/
https://ncbi.nlm.nih.gov/pubmed/23121492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nn3038594
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