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Kinetic characterization of the critical step in HIV-1 protease maturation

HIV maturation requires multiple cleavage of long polyprotein chains into functional proteins that include the viral protease itself. Initial cleavage by the protease dimer occurs from within these precursors, and yet only a single protease monomer is embedded in each polyprotein chain. Self-activat...

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Detalhes bibliográficos
Main Authors: Sadiq, S. Kashif, Noé, Frank, De Fabritiis, Gianni
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528573/
https://ncbi.nlm.nih.gov/pubmed/23184967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210983109
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