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Polymer-attached zanamivir inhibits synergistically both early and late stages of influenza virus infection
Covalently conjugating multiple copies of the drug zanamivir (ZA; the active ingredient in Relenza) via a flexible linker to poly-l-glutamine (PGN) enhances the anti-influenza virus activity by orders of magnitude. In this study, we investigated the mechanisms of this phenomenon. Like ZA itself, the...
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| Hoofdauteurs: | , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2012
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3528545/ https://ncbi.nlm.nih.gov/pubmed/23185023 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219155109 |
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