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Bifunctional Polymeric Inhibitors of Human Influenza A Viruses

PURPOSE: New antiviral agents were prepared by attaching derivatives of sialic acid (1) and of the drug zanamivir (2) to poly(isobutylene-alt-maleic anhydride) (poly-(1+2)) or by mixing poly-1 and poly-2, followed by assaying them against wild-type and drug-resistant influenza A Wuhan viruses. METHO...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Haldar, Jayanta, Álvarez de Cienfuegos, Luis, Tumpey, Terrence M., Gubareva, Larisa V., Chen, Jianzhu, Klibanov, Alexander M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847411/
https://ncbi.nlm.nih.gov/pubmed/20013036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-009-0013-1
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