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Low-affinity B cells transport viral particles from the lung to the spleen to initiate antibody responses

The lung is an important entry site for pathogens; its exposure to antigens results in systemic as well as local IgA and IgG antibodies. Here we show that intranasal administration of virus-like particles (VLPs) results in splenic B-cell responses with strong local germinal-center formation. Surpris...

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Detalhes bibliográficos
Main Authors: Bessa, Juliana, Zabel, Franziska, Link, Alexander, Jegerlehner, Andrea, Hinton, Heather J., Schmitz, Nicole, Bauer, Monika, Kündig, Thomas M, Saudan, Philippe, Bachmann, Martin F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528531/
https://ncbi.nlm.nih.gov/pubmed/23169669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206970109
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