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Cardiac myosin binding protein-C restricts intrafilament torsional dynamics of actin in a phosphorylation-dependent manner

We have determined the effects of myosin binding protein-C (MyBP-C) and its domains on the microsecond rotational dynamics of actin, detected by time-resolved phosphorescence anisotropy (TPA). MyBP-C is a multidomain modulator of striated muscle contraction, interacting with myosin, titin, and possi...

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Main Authors: Colson, Brett A., Rybakova, Inna N., Prochniewicz, Ewa, Moss, Richard L., Thomas, David D.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528524/
https://ncbi.nlm.nih.gov/pubmed/23169656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1213027109
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