Adjunctive β2-agonists reverse neuromuscular involvement in murine Pompe disease

Pompe disease has resisted enzyme replacement therapy with acid α-glucosidase (GAA), which has been attributed to inefficient cation-independent mannose-6-phosphate receptor (CI-MPR) mediated uptake. We evaluated β2-agonist drugs, which increased CI-MPR expression in GAA knockout (KO) mice. Clenbute...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Li, Songtao, Sun, Baodong, Nilsson, Mats I., Bird, Andrew, Tarnopolsky, Mark A., Thurberg, Beth L., Bali, Deeksha, Koeberl, Dwight D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2013
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528321/
https://ncbi.nlm.nih.gov/pubmed/22993195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-207472
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky