Dual suppression of hemangiogenesis and lymphangiogenesis by splice-shifting morpholinos targeting vascular endothelial growth factor receptor 2 (KDR)

The KDR gene, which participates in angiogenesis and lymphangiogenesis, produces two functionally distinct protein products, membrane-bound KDR (mbKDR) and its isoform, soluble KDR (sKDR). Since sKDR does not have a tyrosine kinase domain and does not dimerize, it is principally an antagonist of lym...

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Autori principali: Uehara, Hironori, Cho, YangKyung, Simonis, Jackie, Cahoon, Judd, Archer, Bonnie, Luo, Ling, Das, Subrata K., Singh, Nirbhai, Ambati, Jayakrishna, Ambati, Balamurali K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2013
Soggetti:
Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528308/
https://ncbi.nlm.nih.gov/pubmed/22997228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-213835
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